Silver Sulfadiazene is used to prevent or treat skin infections in patients with serious burns. It may also be used to treat other conditions as determined by your doctor. Silver Sulfadiazene Cream is for topical use only. Clean and dry the affected area before applying the medication. Using a sterile glove, apply a thin film (1/16 inch) of the medication to the affected area and surrounding skin once or twice daily. Continue to use the medication as prescribed for the full time prescribed. Keep the affected area covered with the medication at all times. Do not cover with bandages unless instructed to do so by your doctor. MISSED DOSE: Apply any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.